Best time to take krill oil with dinner or before bed can also be beneficial, especially if you’re already consuming a meal rich in fat, which helps with the absorption of omega-3 fatty acids. Some people prefer to take krill oil in the morning because of its potential to support heart health, brain function, and joint health throughout the day. It can also help with reducing inflammation. Taking krill oil at night might be helpful for sleep quality due to its omega-3 fatty acids. DHA, one of the primary omega-3s in krill oil, has been linked to improved sleep patterns and may support brain health during rest. It can also be easier on the stomach if taken before bed with a larger meal.